Have you had, or do you have, any disease of the liver or kidney? The onset of symptoms generally occurs within minutes to hours of receiving a new or a greater dose of a serotoninergic medications. IMITREX Injection is contraindicated.
IMITREX may cause serious side effects. The following adverse reactions have been identified during postapproval use of IMITREX Tablets, IMITREX Nasal Spray, and Imitrex Injection. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Are you taking any other migraine medicines, including other 5-HT 1 agonists or any other medicines containing ergotamine, dihydroergotamine, or methysergide? How should I store Imitrex Tablets? Contact your doctor if you have more than four headaches in one month 30 days. Tell your doctor if this medicine seems to stop working as well in treating your migraine attacks.
BM, but not one that wouldn't go away within 15-20 mins after. It was a 10 out of 10 pain and I was wailing in pain and could not just stay in a dark room and try and sleep it out. I had my Mom come check on me and she looked up this page and read your post, which told us that hopefully it was just a very very intense migraine, but just be be sure we called my doctor and he instructed us to call the ambulance. Open the Carrying Case lid. The vascular 5-HT 1 receptor subtype to which sumatriptan binds selectively, and through which it presumably exerts its antimigrainous effect, has been shown to be present on cranial arteries in both dog and primate, on the human basilar artery, and in the vasculature of the isolated dura mater of humans. In these tissues, sumatriptan activates this receptor to cause vasoconstriction, an action in humans correlating with the relief of migraine and cluster headache. In the anesthetized dog, sumatriptan selectively reduces the carotid arterial blood flow with little or no effect on arterial blood pressure or total peripheral resistance. In the cat, sumatriptan selectively constricts the carotid arteriovenous anastomoses while having little effect on blood flow or resistance in cerebral or extracerebral tissues.
These drugs are similar to the in this medication and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose to prevent or usually at dosages of 81-325 milligrams a day you should continue taking the aspirin unless your doctor instructs you otherwise. New research shows that in order for triptan-based drug therapy to work effectively in relieving pain, the drugs must be taken early during the attack before the development of exaggerated sensitivity, a symptom often seen in migraine sufferers. If the drugs are taken after this sensitivity develops, the triptans may be rendered powerless against the migraine pain.
This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. The Pen will only work when the Safety Catch is released. To release the Safety Catch, you must press the Pen firmly against your skin until the grey part of the barrel slides against the blue part and it cannot be pressed any further. The grey part of the barrel must stay in contact with the blue part while you inject your medicine. Put the Pen in the Cartridge Pack. You should write down when you have headaches and when you take IMITREX so you can talk with your healthcare provider about how IMITREX is working for you. EC and then taking your naproxen at a different time after your aspirin. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Use: For the acute treatment of cluster headache. What other drugs will affect sumatriptan? Your blood pressure will need to be checked often. What should I discuss with my health care provider before using Imitrex Statdose sumatriptan injection? Drug Interactions: There is no evidence that concomitant use of migraine prophylactic medications has any effect on the efficacy of sumatriptan. ADVERSE REACTIONS section above or those too general to be informative. Syringe Cartridge to the Cartridge Pack. Do not discard the auto-injector. You may use it again with refills of the prefilled syringes. However, if you are using a one-time use auto-injector, discard the auto-injector after use. If you are unsure if your auto-injector can be re-used, ask your pharmacist. Keep all medicines away from children and pets. Number of headaches treated. Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Hold the Pen by the ridges at the top.
No gross overdoses in clinical practice have been reported. Is this headache different from your usual migraine attacks? Break the task down into simple steps. You may find it helpful to give the person written instructions. Sumatriptan can pass into breast milk and may harm a nursing baby. Do not breast-feed within 12 hours after using sumatriptan. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. Combination painkillers. Acetaminophen, aspirin, and caffeine combined into one pill are a safe option for people with blood vessel problems. Cluster headaches don't make you queasy or throw up. But it's possible for someone with cluster headaches to also get migraines, which can have those symptoms. If you have a higher risk for heart problems see Precautions your doctor may perform a heart exam before you start taking sumatriptan. Medicines are sometimes prescribed for purposes other than those listed in Patient Information leaflets. Do not use Imitrex for a condition for which it was not prescribed. Do not give Imitrex to other people, even if they have the same symptoms you have. It may harm them. What should I avoid while taking IMITREX? IMITREX passes into your breast milk and may harm your baby. Talk with your healthcare provider about the best way to feed your baby if you take IMITREX. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. After using sumatriptan nasal spray, you must wait two 2 hours before using a second spray. Do not use more than 40 mg of sumatriptan nasal spray in 24 hours. What happens if I overdose? Imitrex Injection should continue for at least 10 hours or while symptoms or signs persist. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. IMITREX is not used to prevent or decrease the number of migraine or cluster headaches you have. Tell your doctor all medication and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Imitrex Nasal Spray. Your name may need to be listed on a pregnancy registry. Imitrex Nasal Spray passes into breast milk and may harm a nursing baby. Do not breastfeed within 12 hours after using Imitrex Nasal Spray. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.
Pedialyte, to replenish my electrolytes and minerals. Imitrex Injection is not indicated for the prevention of migraine or cluster headache attacks. Your dosage is based on your medical condition and response to therapy. Tell your doctor if your condition does not improve or worsens. Cerena, a small device for people who have an aura before a migraine. You hold it at the back of your head at the first sign of a headache, and it gives off a magnetic pulse that stimulates part of the brain. There was no evidence of an increase in tumors in either species related to sumatriptan administration. This may not be a complete list of all interactions that may occur. Ask your health care provider if Imitrex spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. US Food and Drug Administration "FDA Drug Safety Communication: FDA evaluating the risk of burns and scars with Zecuity sumatriptan migraine patch. The bioavailability is approximately 15%, primarily due to presystemic metabolism and partly due to incomplete absorption. Sumatriptan may also be used for purposes not listed in this medication guide. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Do not store in the bathroom. Do not discard the auto-injector. You may use it again with refills of the prefilled syringes. However, if you are using a one-time use auto-injector, discard the auto-injector after use. If you are unsure if your auto-injector can be re-used, ask your pharmacist. Keep all medicines away from children and pets. Throw away the seal. Open the lid over the Syringe Cartridge. Focus your attention. Often forgetfulness may mean that you have too much on your mind. Slow down and pay full attention to the task you are doing now. Alcohol: Alcohol consumed 30 minutes prior to sumatriptan ingestion had no effect on the pharmacokinetics of sumatriptan. Pen from accidentally firing until you are ready. After using one nasal capsule in each nostril: If your headache does not completely go away, or goes away and comes back, you may use a second dose 1 capsule per nostril if it has been at least two hours since you used the first capsules. Do not use more than two doses 4 nosepieces in 24 hours. If your symptoms do not improve, contact your doctor before using any more sumatriptan nasal capsules. The safety of treating an average of more than 4 headaches in a 30 day period has not been established.
As you age, it is normal to experience some memory lapses. Usually, an occasional memory lapse does not mean you have a serious problem. Nursing Mothers: Sumatriptan is excreted in human breast milk. Therefore, caution should be exercised when considering the administration of IMITREX Injection to a nursing woman. You should not use this medicine if you have uncontrolled high blood pressure, heart problems, certain heart rhythm disorders, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. What should I avoid while taking Imitrex? Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health and perhaps your life at risk. If some response to first dose occurs, a second dose may be administered at least 1 hour after first dose if needed. Fast or slow heartbeat. Frequency not reported: Accommodation disorders, blindness, conjunctivitis, diplopia. For adults, the usual dose is a single injection given just below the skin. Single doses of 5, 10, or 20 mg of Imitrex Nasal Spray administered into 1 nostril were effective for the acute treatment of migraine in adults. Take one sumatriptan tablet whole with a full glass of water. Do not split the tablet. Embryolethality: When given intravenously to pregnant rabbits daily throughout the period of organogenesis, sumatriptan caused embryolethality at doses at or close to those producing maternal toxicity. The mechanism of the embryolethality is not known. Imitrex can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert. Injection: 4-mg and 6-mg single-dose prefilled syringe cartridges for use with the IMITREX STATdose Pen. Medicines to stop headaches aren't working well for you.
The figure shows the probability over time of obtaining headache response no or mild pain following treatment with oral sumatriptan. The averages displayed are based on pooled data from the 3 clinical controlled trials providing evidence of efficacy. Use before you start to use the IMITREX STATdose System. Some of these reactions occurred in patients without known CAD. If your symptoms do not improve after the first dose, do not use a second dose for the same attack. Contact your doctor. Overuse of drugs to treat sudden migraine attacks can lead to worsening of headache medication overuse headache or rebound headache. Therefore, do not use this medication more often or for longer than prescribed. Tell your doctor if you need to use this medication more often, if the medication is not working as well, or if you have more frequent or worse headaches. IMITREX is working for you. IMITREX and certain other medicines can affect each other, causing serious side effects. This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. Cardiovascular: Abdominal aortic aneurysm, angina, atherosclerosis, cerebral ischemia, cerebrovascular lesion, heart block, peripheral cyanosis, phlebitis, thrombosis, and transient myocardial ischemia. Product Information. SUMAtriptan Succinate SUMAtriptan.
You should give an injection as soon as the symptoms of your headache start, but it may be given at any time during a migraine or cluster headache attack. Table 2 below, onset of relief began as early as 10 minutes following a 6-mg IMITREX Injection. Smaller doses of sumatriptan may also prove effective, although the proportion of patients obtaining adequate relief is decreased and the latency to that relief is greater. One will often wake you up an hour or two after you go to bed. Nighttime attacks can be more severe than the daytime ones. GSK group of companies. 10000000124083 Rev. Imitrex tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Imitrex tablets with caution. You can take it as a nasal spray or shot. Pregnant women should not take DHE because it can cause birth defects. Injection in pregnant women. The safety of treating an average of more than 4 headaches in a 30-day period has not been established. There is no evidence that establishes that sumatriptan is a human teratogen; however, there are no adequate and well-controlled studies in pregnant women. IMITREX Injection should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use Imitrex spray with caution in the ELDERLY; the risk of serious side effects eg, heart problems, high blood pressure may be increased. Do not stop taking any medications without consulting your healthcare provider. Other Events Observed in the Clinical Development of IMITREX: The following adverse events occurred in clinical trials with IMITREX Tablets and IMITREX Nasal Spray. Because the reports include events observed in open and uncontrolled studies, the role of IMITREX in their causation cannot be reliably determined. All reported events are included except those already listed, those too general to be informative, and those not reasonably associated with the use of the drug. There may be new information.
Shortness of breath; wheeziness; heart throbbing; swelling of eyelids, face, or lips; or a skin rash, skin lumps, or hives happens rarely. If it happens to you, then tell your doctor immediately. Schoenen J, Bulcke J, Caekebeke J, Dehaene I, Dekeyser J, Hildebrand G, Joffroy A, Laloux P, Louis P, Monseu G, Pierre P, Vander "Self-treatment of acute migraine with subcutaneous sumatriptan using an auto-injector device - comparison with customary treatment in an open, longitudinal study. The pharmacokinetics of sumatriptan in the elderly mean age: 72 years, 2 males and 4 females and in subjects with migraine mean age: 38 years, 25 males and 155 females were similar to that in healthy male subjects mean age: 30 years. Swallow Imitrex tablets whole. Do not break, crush, or chew before swallowing. She prescribed Compazine Prochlorperazine. Imitrex Injection is a clear, colorless to pale yellow, sterile, nonpyrogenic solution for subcutaneous injection. Breasts: Breast swelling, cysts, disorder of breasts, lumps, masses of breasts, nipple discharge, primary malignant breast neoplasm, and tenderness. What should I discuss with my healthcare provider before using sumatriptan? Table 1 lists adverse reactions that occurred in 2 US placebo-controlled clinical trials in migraine patients Studies 2 and 3 following either a single 6-mg dose of Imitrex Injection or placebo. If you have a higher risk for problems see Precautions your doctor may perform a exam before you start taking this medication.
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The Cartridge Pack for the 6-mg strength is blue as shown. I” on one side and “25” on the other in blister packs of 9 tablets NDC 0173-0735-00. Some people may have feelings of tingling, heat, flushing redness of face lasting a short time heaviness or pressure after treatment with IMITREX Injection. A few people may feel drowsy, dizzy, tired, or sick. Tell your doctor of these symptoms at your next visit.
Tablets: White, triangular-shaped, film-coated, and debossed with “I” on one side and “25” on the other. Cmax and AUC were increased by 15% and 12%, respectively, when administered in the fed state. Most people will get daily headaches for 2 weeks to 3 months; in between these periods, they'll be pain-free for at least 2 weeks. About 2 of every 10 people with cluster headaches have less than 14 headache-free days per year. The unit contains only 1 spray. Do NOT test it before use. Pen back into the Carrying Case because that will damage the needle.
Loi V, Lai M, Pisano MR, Delzompo M "Sumatriptan and panic-like symptoms. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take see section. Once the first nosepiece has been administered, press the clear tab and remove the first nosepiece; check to see if the medication is gone from the capsule; discard used nosepiece and repeat with a second nosepiece in the second nostril; it is normal to see a thin white residue after use. Sumatriptan injection comes in a vial bottle an auto-injector or prefilled cartridge to be loaded into an auto-injector syringe, or in a needle-free injector device. Each vial, cartridge, or needle-free device is for one use only.
For patients with risk factors predictive of CAD who are determined to have a satisfactory cardiovascular evaluation, it is strongly recommended that administration of the first dose of sumatriptan injection take place in the setting of a physician's office or similar medically staffed and equipped facility. Because cardiac ischemia can occur in the absence of clinical symptoms, consideration should be given to obtaining on the first occasion of use an electrocardiogram ECG during the interval immediately following IMITREX Injection, in these patients with risk factors. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.